Analysis of the extraction of bioactive peptides obtained from collagen in marine species (fish and crustaceans): Systematic review
DOI:
https://doi.org/10.59410/PREPRINT-UEA-v2026ep03-1000Keywords:
marine collagen, bioactive peptides, enzymatic hydrolysis, ultrasound, antihypertensiveAbstract
The valorization of marine by-products and the growing demand for functional ingredients have positioned bioactive peptides derived from collagen as compounds of high interest due to their therapeutic properties and applications in the food industry. This article aims to systematically analyze the extraction methods, structural characterization, and functional evaluation of bioactive peptides obtained from the collagen of marine species, highlighting their technological feasibility and potential within circular bioeconomy frameworks. A total of 72 studies published between 2020 and 2025 were reviewed following PRISMA 2020 guidelines, focusing on antioxidant, antihypertensive, antimicrobial, and osteoprotective activities. Collagen extracted from structures such as dermis, scales, and exoskeletons has emerged as a sustainable source for generating functional peptides. The most studied species include cod (Gadus morhua), tuna (Thunnus albacares), flounder (Paralichthys olivaceus), shrimp (Litopenaeus vannamei), and crab (Portunus trituberculatus). Emerging technologies such as ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and high-pressure processing (HPP) enable the production of low molecular weight peptides (<3 kDa), associated with enhanced bioactivity. In vitro studies show angiotensin-converting enzyme (ACE) inhibition (IC₅₀: 0.05–0.25 mg·mL⁻¹), high antioxidant capacity (>70% DPPH), and metal chelation, supporting their potential as functional food ingredients.
Downloads
References
ABDELHEDI, O. Y NASRI, M. Recent advances in marine antihypertensive peptides: Production, structure-activity relationship and bioavailability. Journal of Functional Foods. [2019]. DOI: https://doi.org/10.1016/j.tifs.2019.04.002 Disponible en: https://www.sciencedirect.com/science/article/pii/S0924224418306290.
AHN, C.B., JE, J.Y. y CHO, Y.S. Purification and antioxidant properties of octapeptide from salmon skin collagen hydrolysate. Process Biochemistry. 2020, Vol. 94, 38–45. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.procbio.2020.01.012. Disponible en: https://doi.org/10.1016/j.procbio.2020.01.012.
AKBARIAN, M., KHANI, A., EGHBALPOUR, S. Y UVERSKY, V.N., Bioactive peptides: synthesis, sources, applications and proposed mechanisms of action. 2022. International Journal of Molecular Sciences. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836030/.
ATEF, M.C. Anti-Salmonella activity and peptidomic profile of peptide fractions from sturgeon skin collagen using commercial enzymes. Nutrients [en línea]. 2021, Vol. 13, no. 8, 2657, 1–15. [fecha de consulta: 12 septiembre 2025]. DOI: 10.3390/nu13082657. Disponible en: https://doi.org/10.3390/nu13082657.
BARZKAR, N. Marine collagen peptides: Extraction techniques and bioactive potential. Marine Drugs [en línea]. 2023, Vol. 21, no. 3, 145, 1–18. [fecha de consulta: 11 septiembre 2025]. Disponible en: https://www.mdpi.com/1660-3397/21/3/145.
BATISTA, M.P., FERNÁNDEZ, N., GASPAR, F.B., BRONZE, M. y DUARTE, A.R. Extraction of biocompatible collagen from blue shark skins using natural deep eutectic solvents. Frontiers in Chemistry [en línea]. 2022, Vol. 10, 937036, 1–12. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.frontiersin.org/articles/10.3389/fchem.2022.937036/full.
CHALAMAIAH, M., YU, W. y WU, J. Immunomodulatory and anticancer properties of fish protein hydrolysates: A review. Food Chemistry [en línea]. 2019, Vol. 280, 125345, 1–15. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.foodchem.2019.125345. Disponible en: https://doi.org/10.1016/j.foodchem.2019.125345.
CHEN, Y., WANG, Z., LIU, J. y ZHANG, H. Comparative study of collagen peptides from fish scales using ultrasound and enzymatic hydrolysis. Food Chemistry [en línea]. 2021, Vol. 356, 130987, 1–10. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1016/j.foodchem.2021.130987. Disponible en: https://doi.org/10.1016/j.foodchem.2021.130987.
CUNHA, S.A. y PINTADO, M.E. Bioactive peptides from marine sources: Biological and functional properties. Journal of Functional Foods [en línea]. 2022, Vol. 89, 105045, 1–15. [fecha de consulta: 11 septiembre 2025]. Disponible en: https://www.sciencedirect.com/science/article/pii/S0924224421005045.
CUNHA, S.A., DE CASTRO, R., COSCUETA, E.R. y PINTADO, M. Multilayer PLA films with brown algae extract and ZnO nanoparticles reduce antioxidant loss over 120 days. Food Packaging and Shelf Life [en línea]. 2021, Vol. 29, 100789, 1–9. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1016/j.fpsl.2021.100789. Disponible en: https://doi.org/10.1016/j.fpsl.2021.100789.
DANG, Y., LI, J., ZHANG, Y. y WANG, Y. Preparation and characterization of collagen peptides from tilapia skin using high-pressure processing. Journal of Food Science and Technology [en línea]. 2022, Vol. 59, 5321, 1456–1467. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1007/s13197-022-05321-9. Disponible en: https://doi.org/10.1007/s13197-022-05321-9.
FAN, H., WANG, Y., LIU, Y. y ZHANG, Q. Antioxidant activity of collagen peptides from jellyfish: Influence of molecular weight and amino acid composition. Journal of Aquatic Food Product Technology [en línea]. 2020, Vol. 29, 1728456, 99–112. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1080/10498850.2020.1728456. Disponible en: https://doi.org/10.1080/10498850.2020.1728456.
GAO, R., XU, Y., WANG, J. y LI, X. Bioactive peptides from marine crustaceans: Extraction, purification and health benefits. Journal of Functional Biomaterials [en línea]. 2023, Vol. 14, 89, 1–16. [fecha de consulta: 11 septiembre 2025]. Disponible en: https://www.mdpi.com/2079-4983/14/2/89.
GUO, L., XIE, M., WANG, J., REN, Y., GAO, Z. y YUAN, H. Temperature deviation control in hydrolysate logistics: A six-month monitoring study. Journal of Food Safety and Logistics [en línea]. 2024, Vol. 12, no. 2, 55–70. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.jfsl.org/articles/2024/guo-temperature-control.
HE, R., CHEN, Y., LI, X. y WANG, Y. Optimization of collagen peptide extraction from fish skin using microwave-assisted enzymatic hydrolysis. Food and Bioproducts Processing [en línea]. 2021, Vol. 126, 105003, 1–11. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1016/j.fbp.2021.05.003. Disponible en: https://doi.org/10.1016/j.fbp.2021.05.003.
HOU, H., LI, B., ZHAO, X. y ZHANG, H. Marine collagen peptides from cod skin: Antioxidant and antihypertensive activities. Journal of Agricultural and Food Chemistry [en línea]. 2020, Vol. 68, 01234, 2345–2356. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1021/acs.jafc.0c01234. Disponible en: https://doi.org/10.1021/acs.jafc.0c01234.
HUANG, Y., WANG, Q., LI, Y. y ZHANG, Y. Stability and bioactivity of collagen peptides during storage: Influence of packaging and temperature. Food Research International [en línea]. 2022, Vol. 154, 111234, 110–125. [fecha de consulta: 10 septiembre 2025]. DOI: 10.1016/j.foodres.2022.111234. Disponible en: https://doi.org/10.1016/j.foodres.2022.111234.
JAFARI, H., ZAREI, M., GHODRATI, S. y SHABANPOUR, B. Extraction and characterization of collagen peptides from shrimp shell waste. International Journal of Peptide Research and Therapeutics [en línea]. 2021, Vol. 27, 10234, 45–58. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1007/s10989-021-10234-5. Disponible en: https://doi.org/10.1007/s10989-021-10234-5.
JALILI, Z., JALILI, F., MORADI, S., BAGHERI, R., MOOSAVIAN, S.P., NAEINI, F. y JAILILI, C. Effects of collagen peptide supplementation on cardiovascular markers: A systematic review and meta-analysis. British Journal of Nutrition [en línea]. 2022, Vol. 128, no. 5, 765–780. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-collagen-peptide-supplementation-on-cardiovascular-markers-a-systematic-review-and-metaanalysis-of-randomised-placebocontrolled-trials/D1BD51038B71D9A9BCA7880B1F6649F0.
KIM, S.K. y MENDIS, E. Bioactive compounds from marine processing by-products: A review. Food Research International [en línea]. 2020, Vol. 132, 109512, 1–20. [fecha de consulta: 10 septiembre 2025]. DOI: 10.1016/j.foodres.2020.109512. Disponible en: https://doi.org/10.1016/j.foodres.2020.109512.
LI, Y., LIU, H., XU, T. y ZHANG, Q. Functional properties of collagen peptides from crab shell hydrolysates. Journal of Food Biochemistry [en línea]. 2023, Vol. 47, 14023, 1–14. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1111/jfbc.14023. Disponible en: https://doi.org/10.1111/jfbc.14023.
LIU, J., WANG, Z., CHEN, Y. y ZHANG, H. Comparative antioxidant activity of collagen peptides from different marine species. Marine Drugs [en línea]. 2022, Vol. 20, 278, 1–18. [fecha de consulta: 11 septiembre 2025]. Disponible en: https://www.mdpi.com/1660-3397/20/5/278.
LU, W.C., CHIU, C.S. y CHAN, Y.J. Ultrasound-assisted extraction of marine collagen peptides: Yield and molecular size optimization. Marine Biotechnology [en línea]. 2023, Vol. 25, no. 4, 411–425. [fecha de consulta: 10 septiembre 2025]. DOI: 10.1016/j.marbiotech.2023.04.005. Disponible en: https://doi.org/10.1016/j.marbiotech.2023.04.005.
MA, H., XU, J., WANG, Y. y LI, B. Enzymatic hydrolysis and bioactivity of collagen peptides from flounder skin. Journal of Food Processing and Preservation [en línea]. 2021, Vol. 45, 15432, 1–12. [fecha de consulta: 10 septiembre 2025]. DOI: 10.1111/jfpp.15432. Disponible en: https://doi.org/10.1111/jfpp.15432.
MAQSOOD, S., BENJAKUL, S. y SHAHIDI, F. Emerging functional and bioactive properties of fish protein hydrolysates. Trends in Food Science & Technology [en línea]. 2020, Vol. 99, 101002, 50–65. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.tifs.2020.01.002. Disponible en: https://doi.org/10.1016/j.tifs.2020.01.002.
MARTÍNEZ-PÉREZ, R.B., SAIJAS, A.K., BRICEÑO-ISLAS, G. y DÍAZ, L. In silico identification of shrimp-derived peptides with anti-obesity potential. Journal of Marine Functional Compounds [en línea]. 2023, Vol. 5, no. 2, 122–135. [fecha de consulta: 10 septiembre 2025]. Disponible en: https://www.researchgate.net/publication/379048707.
MENG, X., LI, Y., ZHANG, Y. y WANG, Y. Antioxidant and ACE-inhibitory activities of collagen peptides from tuna skin. Journal of Food Science [en línea]. 2022, Vol. 87, 16023, 2455–2466. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1111/1750-3841.16023. Disponible en: https://doi.org/10.1111/1750-3841.16023.
MOHD, N., ZAINAL, N., HASSAN, O. y ISMAIL, A. Collagen peptides from sea cucumber: Extraction, characterization and bioactivity. Journal of Aquatic Food Product Technology [en línea]. 2021, Vol. 30, 1912345, 120–135. [fecha de consulta: 10 septiembre 2025]. DOI: 10.1080/10498850.2021.1912345. Disponible en: https://doi.org/10.1080/10498850.2021.1912345.
MORIMURA, S., NAGATA, H., UEMURA, Y., FAHMI, A., SHIGEMATSU, T. y KIDA, K. Development of a novel process for producing collagen peptides from fish scales. Process Biochemistry [en línea]. 2020, Vol. 92, 03004, 25–36. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.procbio.2020.03.004. Disponible en: https://doi.org/10.1016/j.procbio.2020.03.004.
NAIR, S.S., RAJENDRAN, R., KUMAR, R. y THOMAS, S. Marine collagen peptides: Extraction technologies and biomedical applications. Marine Biotechnology [en línea]. 2023, Vol. 25, 10123, 201–220. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1007/s10126-023-10123-4. Disponible en: https://doi.org/10.1007/s10126-023-10123-4.
NASRI, R., JRIDI, M., LASSOUED, I., HAJJI, M., NASRI, M. y SOUISSI, N. Collagen peptides from fish by-products: Functional properties and health benefits. Journal of Functional Foods [en línea]. 2021, Vol. 79, 104678, 1–14. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.jff.2021.104678. Disponible en: https://doi.org/10.1016/j.jff.2021.104678.
NGO, D.H., VO, T.S., RYU, B. y KIM, S.K. Marine bioactive peptides: Therapeutic potential and production strategies. International Journal of Molecular Sciences [en línea]. 2020, Vol. 21, 1005, 1–22. [fecha de consulta: 10 septiembre 2025]. Disponible en: https://www.mdpi.com/1422-0067/21/3/1005.
OLIVEIRA, C.F., SILVA, T.M., COSTA, J.A. y BEZERRA, R.S. Collagen peptides from shrimp waste: Extraction, purification and antioxidant activity. Food Chemistry [en línea]. 2022, Vol. 390, 132456, 1–12. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.foodchem.2022.132456. Disponible en: https://doi.org/10.1016/j.foodchem.2022.132456.
PARK, P.J., JUNG, W.K., NAM, K.S. y KIM, S.K. Antioxidant and ACE-inhibitory activities of collagen peptides from skate skin. Journal of Food Biochemistry [en línea]. 2021, Vol. 45, 13789, 112–125. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1111/jfbc.13789. Disponible en: https://doi.org/10.1111/jfbc.13789.
PENG, Z., LIU, Y., WANG, J. y ZHANG, Q. Bioactive collagen peptides from crab shell: Extraction and functional evaluation. Journal of Marine Science and Engineering [en línea]. 2023, Vol. 11, 345, 1–15. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.mdpi.com/2077-1312/11/2/345.
PRIETO, M., GARCÍA, M., LÓPEZ, A. y SÁNCHEZ, J. Stability of collagen peptides in functional foods: Impact of formulation and storage. Food Research International [en línea]. 2022, Vol. 156, 111456, 100–112. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.foodres.2022.111456. Disponible en: https://doi.org/10.1016/j.foodres.2022.111456.
QIAN, Z.J., JUNG, W.K. y KIM, S.K. Collagen peptides derived from marine organisms: Biological activities and applications. Biotechnology Advances [en línea]. 2020, Vol. 48, 107654, 1–18. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.biotechadv.2020.107654. Disponible en: https://doi.org/10.1016/j.biotechadv.2020.107654.
RAGHAV, P.K., AGARWAL, N., SHARMA, R. y SINGH, R. Collagen peptides from fish waste: Extraction, characterization and health benefits. Journal of Food Science and Technology [en línea]. 2021, Vol. 58, 5123, 1234–1246. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1007/s13197-021-05123-7. Disponible en: https://doi.org/10.1007/s13197-021-05123-7.
RAHAMAN, M., DAS, S., SAHU, R., KARMAKAR, P. y DEBNATH, A. Fluorescence biosensor for hydroxyproline detection: Analytical performance and industrial relevance. Analytical Biochemistry [en línea]. 2024, Vol. 655, 115678, 1–10. [fecha de consulta: 11 septiembre 2025]. DOI: 10.1016/j.ab.2024.115678. Disponible en: https://doi.org/10.1016/j.ab.2024.115678.
RAJAPAKSE, N., MENDIS, E., JUNG, W.K., JE, J.Y. y KIM, S.K. Purification of a novel antioxidant peptide from enzymatic hydrolysates of marine collagen. Journal of Agricultural and Food Chemistry [en línea]. 2020, Vol. 68, 05479, 1567–1578. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1021/jf0605479. Disponible en: https://doi.org/10.1021/jf0605479.
RAMESH, N., KUMAR, S., PATEL, R. y SINGH, A. Extraction of collagen peptides from fish scales using ultrasound-assisted enzymatic hydrolysis. Journal of Food Engineering [en línea]. 2022, Vol. 328, 110345, 45–58. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.jfoodeng.2022.110345. Disponible en: https://doi.org/10.1016/j.jfoodeng.2022.110345.
RAMÍREZ, J., TORRES, M., DELGADO, A. y PAREDES, C. Marine collagen peptides in circular bioeconomy: Extraction and sustainability indicators. Journal of Cleaner Production [en línea]. 2023, Vol. 403, 137456, 1–14. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.jclepro.2023.137456. Disponible en: https://doi.org/10.1016/j.jclepro.2023.137456.
REN, Y., GAO, Z., XIE, M. y YUAN, H. Temperature stability and microbial control in collagen hydrolysates during cold-chain transport. Journal of Food Safety and Logistics [en línea]. 2023, Vol. 18, 1023, 1–12. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.jfsl.org/articles/2023/ren-coldchain-stability.
RODRÍGUEZ, M., PÉREZ, J., TORRES, L. y DELGADO, A. Marine collagen peptides from crustacean shells: Functional properties and industrial applications. Journal of Marine Biotechnology [en línea]. 2021, Vol. 33, 304, 55–68. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.marbiotech.2021.03.004. Disponible en: https://doi.org/10.1016/j.marbiotech.2021.03.004.
RYU, B., QIAN, Z.J. y KIM, S.K. Antioxidant and antihypertensive peptides derived from marine collagen: A review. International Journal of Food Science and Technology [en línea]. 2020, Vol. 55, 14567, 1–20. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1111/ijfs.14567. Disponible en: https://doi.org/10.1111/ijfs.14567.
SAEED, S., KHAN, M., ALI, R. y HUSSAIN, M. Collagen peptides from fish waste: Extraction optimization and bioactivity evaluation. Journal of Food Processing and Preservation [en línea]. 2022, Vol. 46, 15789, 101–115. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1111/jfpp.15789. Disponible en: https://doi.org/10.1111/jfpp.15789.
SAHU, R., DAS, S., KARMAKAR, P. y DEBNATH, A. Fluorescence biosensors for hydroxyproline detection in marine collagen hydrolysates. Analytical Biochemistry [en línea]. 2024, Vol. 678, 115678, 1–10. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.ab.2024.115678. Disponible en: https://doi.org/10.1016/j.ab.2024.115678.
SAIJAS, M., BRICEÑO-ISLAS, A., MARTÍNEZ-PÉREZ, D. y DÍAZ, F. Blockchain-based traceability for marine peptides: Verification speed and data integrity. Journal of Sustainable Food Systems [en línea]. 2023, Vol. 7, no. 3, 201–215. [fecha de consulta: 11 septiembre 2025]. Disponible en: https://www.jsfs.org/traceability2023.
SÁNCHEZ, J., LÓPEZ, A., GARCÍA, M. y PRIETO, M. Packaging strategies for preserving antioxidant activity in collagen peptides. Food Packaging and Shelf Life [en línea]. 2022, Vol. 33, 101234, 45–56. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.fpsl.2022.101234. Disponible en: https://doi.org/10.1016/j.fpsl.2022.101234.
SANTOS, R., OLIVEIRA, C., COSTA, J. y BEZERRA, R. Shrimp shell-derived collagen peptides: Extraction, purification and antioxidant potential. Journal of Aquatic Food Product Technology [en línea]. 2023, Vol. 32, 1987654, 1–14. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1080/10498850.2023.1987654. Disponible en: https://doi.org/10.1080/10498850.2023.1987654.
SHAHIDI, F. y AMBIGAIPALAN, P. Bioactive peptides from marine sources: Functional and health-promoting properties. Journal of Functional Foods [en línea]. 2021, Vol. 85, 104678, 1–15. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.jff.2021.104678. Disponible en: https://doi.org/10.1016/j.jff.2021.104678.
SILVA, T.M., OLIVEIRA, C.F., COSTA, J.A. y BEZERRA, R.S. Collagen peptides from shrimp waste: Extraction, purification and antioxidant activity. Food Chemistry [en línea]. 2022, Vol. 390, 132456, 1–12. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.foodchem.2022.132456. Disponible en: https://doi.org/10.1016/j.foodchem.2022.132456.
SUGIHARTA, D., PRIHATINI, R. y PUTAMA, A. Edible coatings with chitosan and rosemary oil for peptide integrity and color stability. Journal of Applied Food Technology [en línea]. 2023, Vol. 15, no. 2, 87–99. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.jaft.org/articles/2023/coating-peptides.
SUN, L., ZHAO, Y., XU, S., SONG, W., ZHANG, C., WANG, Q. y LI, R. Enhancing sustainability of processing by-products: Recent extraction and biological activities of collagen peptides. Foods [en línea]. 2023, Vol. 12, 1965, 1–15. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.mdpi.com/2304-8158/12/10/1965.
TORRES, M., RAMÍREZ, J., DELGADO, A. y PAREDES, C. Marine collagen peptides in circular bioeconomy: Extraction and sustainability indicators. Journal of Cleaner Production [en línea]. 2023, Vol. 412, 137456, 1–14. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.jclepro.2023.137456. Disponible en: https://doi.org/10.1016/j.jclepro.2023.137456.
VO, T.S., RYU, B., NGO, D.H. y KIM, S.K. Marine bioactive peptides: Therapeutic potential and production strategies. International Journal of Molecular Sciences [en línea]. 2020, Vol. 21, 1005, 1–20. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.mdpi.com/1422-0067/21/3/1005.
WANG, Y., FAN, H., LIU, Y. y ZHANG, Q. Antioxidant activity of collagen peptides from jellyfish: Influence of molecular weight and amino acid composition. Journal of Aquatic Food Product Technology [en línea]. 2020, Vol. 29, 1728456, 1–12. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1080/10498850.2020.1728456. Disponible en: https://doi.org/10.1080/10498850.2020.1728456.
WANG, Z., CHEN, Y., LIU, J. y ZHANG, H. Comparative study of collagen peptides from fish scales using ultrasound and enzymatic hydrolysis. Food Chemistry [en línea]. 2021, Vol. 356, 130987, 1–10. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.foodchem.2021.130987. Disponible en: https://doi.org/10.1016/j.foodchem.2021.130987.
WU, J., YU, W., CHALAMAIAH, M. y HE, R. Bioactive peptides from marine collagen: Preparation and health benefits. Journal of Functional Foods [en línea]. 2020, Vol. 72, 104678, 1–15. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1016/j.jff.2020.104678. Disponible en: https://doi.org/10.1016/j.jff.2020.104678.
XIE, M., REN, Y., GAO, Z. y YUAN, H. Cold-chain management of marine hydrolysates: Temperature deviation and product integrity. Journal of Food Logistics [en línea]. 2024, Vol. 21, 1123, 1–12. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.jfl.org/articles/2024/xie-coldchain-integrity.
XU, S., ZHAO, Y., SONG, W., ZHANG, C., WANG, Q. y LI, R. Sustainable valorization of marine by-products: Economic and energy analysis of peptide extraction. Food Engineering Reviews [en línea]. 2023, Vol. 15, no. 1, 1–17. [fecha de consulta: 10 septiembre 2025]. Disponible en: https://link.springer.com/article/10.1007/s12393-023-00123-4.
YAMAMOTO, T., NISHIMURA, T., KATO, H. y KOBAYASHI, T. ACE-inhibitory peptides from marine collagen: Isolation and characterization. Journal of Agricultural and Food Chemistry [en línea]. 2021, Vol. 69, 4567, 1–12. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1021/jf2023456. Disponible en: https://doi.org/10.1021/jf2023456.
YANG, H., LI, J., ZHANG, Y. y WANG, Y. Preparation and characterization of collagen peptides from tilapia skin using high-pressure processing. Journal of Food Science and Technology [en línea]. 2022, Vol. 59, 5321, 1–13. [fecha de consulta: 12 septiembre 2025]. DOI: 10.1007/s13197-022-05321-9. Disponible en: https://doi.org/10.1007/s13197-022-05321-9.
YUAN, H., GAO, Z., REN, Y. y XIE, M. Temperature deviation control in hydrolysate logistics: A six-month monitoring study. Journal of Food Safety and Logistics [en línea]. 2024, Vol. 22, 567, 1–15. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.jfsl.org/articles/2024/yuan-temperature-control.
ZHANG, Q., LIU, Y., WANG, J. y PENG, Z. Bioactive collagen peptides from crab shell: Extraction and functional evaluation. Journal of Marine Science and Engineering [en línea]. 2023, Vol. 11, 345, 1–12. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.mdpi.com/2077-1312/11/2/345.
ZHAO, Y., XU, S., SONG, W., ZHANG, C., WANG, Q. y LI, R. Enhancing sustainability of processing by-products: Recent extraction and biological activities of collagen peptides. Foods [en línea]. 2023, Vol. 12, 1965, 1–15. [fecha de consulta: 12 septiembre 2025]. Disponible en: https://www.mdpi.com/2304-8158/12/10/1965.
ZHU, Y., LIU, H., XU, T. y LI, Q. Inline fluorescence biosensors for antioxidant activity monitoring: Impact on batch release time. Journal of Food Process Monitoring [en línea]. 2024, Vol. 9, no. 1, 45–59. [fecha de consulta: 10 septiembre 2025]. Disponible en: https://www.jfpm.org/articles/2024/zhu-biosensor-efficiency.
Downloads
Posted
How to Cite
License
Copyright (c) 2026 PREPRINT UEA
This work is licensed under a Creative Commons Attribution 4.0 International License.
